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KMID : 0360319920240030365
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 3 p.365 ~ p.377
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Lymphokine-Activated Killer(LAK) Cell Activity in Tumor-Transplanted Mice(II)
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남상윤
이연태/김영일/김시영/조경삼
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Abstract
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In the previous report we demonstrated the decline of lymphokine-activated killer(LAK) cell activity in tumor-transplanted mice and that it resulted from impaired differentiation of LAK precursors to effector cells rather than the decrease in
number of
precursor cells. In the present study we tested several factors for their involvement in the decline of LAK cell activity.
The declined LAK cell activity of tumor-transplanted mice was not restored by high doses of IL 2 nor with prolonged incubation and inhibitory factors to LAK cell inducton were not detected in the serum of tumor-transplanted mice.
NK cell activity were changed precedently to the change of LAK cell activity with similar fashion. This finding suggested that the change of LAK cell activity may be related to the change of NK cell activity.
Experiments of antibody complement lysis demonstrated that the decreased LAK cell activity in tumor-transplanted mice was partially reversed by removal of adherent Mac-1+ cells. And the partially reveres LAK cell activity was further increased by
addition of conditioned media(LAK cell culture supernatant) as differentiation factors which may be endogeneously released during LAK cell induction in normal mice.
From the above results, it was concluded that the decline of LAK cell activity in tumortransplanted mice resulted from the suppressive effect of Mac-1+ cells and defective production of LAK cell differentiation factor(s) by 2-responding cells.
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